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The predicted human PK parameters were used to define the escalation steps in this study, while information from nonclinical toxicology studies was used to define the starting dose, following the recommendations of the ICH-S9 Guidance Document

Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor

Group comparisons in Glu, Gln, and GABA levels ANCOVA revealed significant diagnostic effects on Gln levels in the thalamus ( p = 0.008) and the rTPJ ( p = 0.006), indicating higher Gln levels in these regions in individuals with ASD (Table 2, Fig

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